Authors
Ala Eldin Choukaife - Loai Aljerf
Abstract
In pharmaceutical sulphonamides, vapour-programmed thin-layer chromatography (VP-TLC) was implemented using Silica Gel GF254 in the separation and characterisation of sulphonamides. The outcomes of this method have been compared with thin layer chromatographic (TLC) process. 15 chemical substances were resolved in a neutral and alkali media. Results are far from optimal. With ether-methanol (90: 10) the first seven substances are reasonably separated but the remaining eight all show about the same migration. Furthermore, it should be noticed that only about 3/5 of the plate is utilised for the spread. Unsaturated chambers did not improve the separation significantly. Only sulphamethoxypyridazine and sulphisoxazole did not separate under these conditions, but the other components are well separated and migrated throughout the whole lane. It should be noted that the VP-systems described are suitable for two-dimensional development. Thus, it can be concluded that VP-TLC is highly effective in the analysis of sulphonamides
Keywords
Thin layer chromatographic; Sulphamethoxypyridazine; Pharmaceutical analysis; Anaesthetics; Amphoteric
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