Management of hepatitis C virus genotype 4: Recommendations of An International Expert Panel

 : Authors

"> Mahmoud A. Khattab1,⇑, Peter Ferenci2, Stephanos J. Hadziyannis3, Massimo Colombo4,
Michael P. Manns5, Piero L. Almasio6, Rafael Esteban7, Ayman A. Abdo8, Stephen A. Harrison9,
Nazir Ibrahim10, Patrice Cacoub11, Mohammed Eslam1, Samuel S. Lee12

:Abstract

HCV has been classified into no fewer than six major genotypes and a series of subtypes. Each HCV genotype is unique with respect to its nucleotide sequence, geographic  distribution, and response to therapy. Genotypes 1, 2, and 3 are common throughout North America and Europe. HCV genotype 4 (HCV-4) is common in the Middle East and in  Africa, where it is responsible for more than 80% of HCV infections. It has recently spread to several  uropean countries. HCV-4 is considered a major cause of chronic hepatitis, cirrhosis, hepatocellular carcinoma, and liver transplantation in these regions. Although HCV-4 is the cause of approximately 20% of the 170 million cases of chronic hepatitis C in
the world, it has not been the subject of widespread research. Therefore, this document, drafted by a panel of international experts, aimed to review current knowledge on the  epidemiology, natural history, clinical, histological features, and treatment of HCV-4 infections.

 

 

 

 

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