Groob Alkhayer, Mhd Nezar Alsharif* and Maiass El Homsi
World Journal of Pharmaceutical Research, Vol 7, Issue 10, 2018
Objective: This study aimed to determine the most common age, presentation (symptoms and signs) of acute bacterial meningitis (ABM) for each age group, the most common pathogens responsible for it and the cerebrospinal fluid (CSF) analysis of ABM cases.
Methods: This is a retrospective study composed of all children (newborns until 12 years old); who reviewed the Children University Hospital Between 1/1/2015 and 20/11/2017 and were diagnosed with acute bacterial meningitis. Results: This study included 55 patients. Most of the participants were boys between (1 month -6 months) old. The most common results of CSF culture in our study were sterile (23 cases of all patients). In addition, the most common pathogen was Streptococcus pneumonia (13 cases of all patients). The most common symptom-sign for each age group (<month, 1 month-6 months, 6 months- 1 year, 1 year- 6 years and 6 years- 12 years) was (poor breastfeeding-hyperreflexia, poor breastfeeding and convulsion equally-bulging fontanelle, fever- bulging fontanelle, fever- positive Neck Stiffness, upper Brudzinski, lower Brudzinski, Kernig equally and fever-neck stiffness, upper Brudzinski equally), respectively. CSF analysis revealed 23.6% of all patients had a WBC count (more than 100 cell/mm3), 18.1% had polymorph nuclear neutrophils dominance and 38.2% had low glucose levels in the CSF. All of the following opposes the diagnosis of bacterial meningitis and suggests different causes of meningitis. This could be related to incomplete or incorrect previous antibiotic therapy. Conclusion: We found that acute bacterial meningitis (ABM) is most common in boys between (1 month- 6 months) old. The most common pathogen causing ABM is streptococcus pneumoniae while the most common culture result was sterile. The mortality
rate in our study was 21.8% (12 patients).