Author

Nasser Thallaj

Abstract

One of the most fascinating aspects of enzymes is the way these biological catalysts have been designed in order to be able to carry out highly selective reactions under mild conditions. Controlled modification and artificial tuning of Nature’s legacy, using molecular biology technices together with new chemical methods in the field o f bioorganic syntheses, led chemists to investigate access to modified proteins, going as far as designing artificial enzymes. The result is sometimes surprising, since new enzyme activity can be found from modified proteins, Reaction of a two fold molar excess of ligands of DPAs with -8-BromoAc4riboflavin in dry DMF over 24 hours affords the -8-DPAs N- Ac4riboflavin ligands. This compound can be described as a tweezers in which the flavin moiety acts as a potential electron mediator

Keywords

N ligands / Riboflavin /Electron Mediator