Endotoxin receptorCD14 gene variants and histological features in chronic HCV infection

 

: Authors

Eva Askar, Giuliano Ramadori, Sabine Mihm

Published in

2009 The WJG Press and Baishideng

:Abstract

 AIM: To analyze the correlation between CD14 rs2569190/C-159T single nucleotide polymorphism (SNP) and disease progression in chronic hepatitis C. METHODS: Liver   biopsy specimens from a total of  137 and 349 patients with chronic hepatitis C were separately evaluated with respect to necroinflammatory activity (grading) and architectural   changes (staging). In one group, further histological lesions characteristic for hepatitis C, hepatitis C virus subtypes, and biochemical parameters of liver disease were also  investigated .Samples of genomic DNA were genotyped for the respective SNP by 5’-nuclease assays using fluorescent  dye-labeled allele-specific probes.
RESULTS: Genotype distribution did not deviate from the Hardy-Weinberg equilibrium. In the first group, patients homozygous for the variant allele T were found to be younger than  C allele carriers (39.6 ± 12.5 vs 45.7 ± 11.5, P = 0.008). Among the histological lesions studied, portal lymphoid aggregates were more frequently observed among TT  homozygotes than among C carriers (21/37 vs 32/100, P = 0.008). The presence of portal lymphoid aggregates was closely correlated with hepatic inflammation (P = 0.003) and with bile duct damage (P < 0.001). The degree of fibrosis, in contrast, was not found to be related to the CD14 gene C-159T polymorphism.

Keywords

CD14; Endotoxins; Hepatitis C virus; Inflammation; Lipopolysaccharides; Liver fibrosis; Portal system; Single nucleotide polymorphism

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