Authors

Dr. med dent Aous Dannan

Abstract

The Periodontal Ligament (PDL) is derived embryologically from the ecto-mesenchymal tissue of the dental follicle that surrounds the developing tooth in its bony crypt. The presence of stem cells in the PDL was supported by several findings where a population of mesenchymal stem cells from the PDL has been isolated and characterized showing the ability to express a variety of stromal cells markers. In this review, we demonstrated our own experience with human Periodontium-derived Stem Cells (PdSCs) starting by uncovering
their characterizations in vitro, and ending up with showing the ability of such cells to regenerate periodontal tissues in vivo. However, a systematic search in the literature for all articles related to PdSCs is not the aim of this paper. Our experiments showed that human adult PdSCs could differentiate into cementoblasts or osteoblasts to support periodontal
regeneration. After being transplanted into an athymic rat model, PdSCs were able to regenerate periodontal tissue elements at different levels. More optimized controlled methods should be established when such human PdSCs are to be used

Published in

Received: June 07, 2015; Accepted: September 24, 2015; Published: October 08, 2015

HSOA Journal of Stem Cells Research, Development and Therapy

Keywords

Animal model; Periodontal ligament; Regeneration; Stem cells