Drug Synthesis

 

 

Drug Synthesis

[1st semester, 2018-2019]

Instructor Information

Instructor

Email

Office Location & Hours

Pr. Anas Rajab

anasrajab@gmail.com

[Faculty of Pharmacy, 1-3 pm, Sunday, Tuesday, Wednesday]

General Information

Description

The course includes following chapters explaining the rules and methods for synthesis of pharmaceutical active raw materials according to their pharmacological groups and studying the spectral methods for detection there formula structure.  

 Expectations and Goals

This course aims to provide the student with the following:

1 – The importance, for a medicinal chemist, of having adequate information about chemical groups and their reactions and uses in drug synthesis.

2- Identification synthetic organic compounds by using spectroscopic methods (NMR, MS, IR, UV).

3- How to propose chemical chart for any chemical organic formula to be synthetized starting from lead compound.

4- Synthesizing or semi synthesizing some drugs which have aromatic and hetero aromatic rings

 

Language(s) of Instruction:  Arabic                  Textbook(s) Language(s) : Arabic

Course Materials

Required Text

Chemistry for Pharmacy Students; Satyajit D. Sarker, Lutfun Nahar ; john Wiley& sonc, Ltd , 2007 (ورقي ).

Course Schedule

 

Week

Topic

Reading

Exercises

1

22/9 – 27/9

Introduction

 

 

2

29/9 – 4/10

Chemical reactions that are used in medicinal synthesis and the main rules of organic synthesis

 

 

3

6/10 – 11/10

Ultraviolet and infrared spectroscopy (IR, UV)

 

 

4

13/10 – 18/10

Mass spectrometry and NMR spectroscopy (H1NMR, C13NMR, MS)

 

 

5

20/10 – 25/10

Synthesis of Semi-finished materials

 

 

6

27/10 – 1/11

study of some general methods in drug synthesis that based on the benzene ring substituted.

 

 

7

3/11 – 8/11

Synthesis of nonsteroidal anti-inflammatory drugs (NSAID’s)

 

 

8

10/11 – 15/11

study of some general methods in drug synthesis that based on the Rings Heterocyclic

 

 

9

17/11 – 22/11

study of some general methods in drug synthesis that based on the Rings Heterocyclic

 

 

10

24/11 – 29/11

study of some general methods in drug synthesis of steroid drugs

 

 

11

1/12 -6/12

study of some general methods in drug synthesis of antibiotics (Sulfamide compounds)

 

 

12

8/12 – 13/12

study of some general methods in drug synthesis of antibiotics (penicillines)

 

 

13

15/12 – 20/12

study of some general methods in drug synthesis of antibiotics (penicillin family)

 

 

14

22/12 – 27/12

study of some general methods in drug synthesis of antibiotics (cephalosporin family )

 

 

15

29/12 – 3/1

study of some general methods in drug synthesis of drugs sugar

 

 

Testing Schedule :

test

Date

Subject

Reading

Type

language

% of final grade

Quizz 1

27/10 till 1/11

First 6 chapters

Chapter/pp

written

Arabic

5%

Quizz 2

8/12 till 13/12

Last 6 chapters

Chapter/pp

written

Arabic

5%

Final

5/1 till 17/1

All chapters

Chapter/pp

written

Arabic

60%

 

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